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Language Skills

R
Bash
Git/GitHub
Python

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Made with the R package pagedown.

The source code is available on github.com/dzhang32/cv.

Last updated on 2021-02-24.

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David Zhang

TBA

Education

Research assistant, part-time PhD, Bioinformatics

University College London

London, UK

Present - 2017

  • Thesis: Using transcriptomics to improve the diagnosis rate of rare disease patients.
  • Ultimately, the goal of my PhD is to develop and apply statisical methods and software that improve the genetic diagnosis rate using RNA-sequencing. This involves detection of aberrant RNA-level events when complemented with, DNA sequencing help to resolve variants of unknown significance.

MSc, Neuroscience

University College London

London, UK

2016 - 2015

  • Thesis: The role of mitochondrial dysfunction in Xerodoma pigmentosum
  • Grade: Merit (68%)
  • Awarded post-graduate support scheme bursary (£10,000)

BSc, Biomedical science

University College London

London, UK

2015 - 2012

  • Thesis:
  • Grade: 2:1 (69%)

H.S.

Queen Elizabeth’s School

Barnet, UK

2012 - 2007

  • Grade: Maths (A*), Biology (A*), Chemistry (A*), Sociology (A).



Research Experience

Honorary Researcher (2 months)

Johns Hopkins Bloomberg School of Public Health

Remote

2020

  • In collaboration with Leonardo Collado-Torres, we used the recount3 dataset and LIBD samples to study the effect of complex splicing in individuals with neurological disease.

Research Technician

University College London

London, UK

2017 - 2016

  • Used R and bash to investigate the effect of genetic variation on the age of onset of dementia and cognition within Down syndrome patients.



Industry Experience

Bioinformatician internship (3 months)

Verge Genomics

Remote

2020

  • Detection of aberrant splicing events in complex disease patients.
  • Using AWS infrastructure



Software & programming

Bioconductor packages

N/A

N/A

Present - 2020

  • dasper: detection of aberrant splicing events in RNA-sequencing. Author and maintainer. XXX downloads.
  • megadepth: BigWig and BAM related utilities. An R wrapper for the megadepth software developed. Co-author and maintainer. XXXX downloads.

Chess analysis

N/A

N/A

2021

  • Applying python and data science principles through the analysis of chess data.

Advanced R

N/A

N/A

2021 - 2020

Kaggle town

N/A

N/A

2020

  • Organised club to study python and machine learning through kaggle problems.

Data wrangling

Neuroimmunology & CSF Laboratory, NHS

London, UK

2018 - 2016

  • Developer and maintainer of data wrangling pipelines that improved the efficiency and standardisation of monthly financial reports.

Teaching Experience

Developing Bioconductor Packages

University College London

Virtual Event

2020

Unit testing using testthat edition 3

rstats club

Virtual Event

2020

  • Talk regarding unit testing fundamentals, the importance of testing and new features released in the R package testthat edition 3.

R fundamentals

Clinician Coders

London, UK

2020 - 2018

  • Developed materials and lead facilitator for teaching R to clinicians.

RNA-sequencing for diagnostics

Kings College London

London, UK

2020 - 2017

  • Invited lecturer to graduate level students on how transcriptomics can be applied in the diagnostic pipeline.



Selected Publications

Megadepth: efficient coverage quantification for BigWigs and BAMs

Bioinformatics

N/A

2020

  • Authored with Richard Single, Vanja Paunic, Mark Albrecht, and Martin Maiers.